An Integrative Method for Accurate Comparative Genome Mapping
نویسندگان
چکیده
منابع مشابه
An Integrative Method for Accurate Comparative Genome Mapping
We present MAGIC, an integrative and accurate method for comparative genome mapping. Our method consists of two phases: preprocessing for identifying "maximal similar segments," and mapping for clustering and classifying these segments. MAGIC's main novelty lies in its biologically intuitive clustering approach, which aims towards both calculating reorder-free segments and identifying orthologo...
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Department of Agronomy, Iowa State University, Ames, Iowa 50011 (A.J.S., G.A.P., R.C.S.); Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota 55455 (W.W.X.); Soybean Genomics and Improvement Laboratory, United States Department of Agriculture-Agricultural Research Service, Beltsville, Maryland 20705 (D.L.H.); United States Department of Agriculture-Agricultural R...
متن کاملComparative Genome Mapping
Some terms: Orthologous loci: loci in different species originating from the same ancestral locus paralagous loci: loci in different (or the same) species that arose due to a duplication of an ancestral locus synteny: a similar linear order of markers in two different species (or on two different linkage groups, as in soybean or Brassica) microsynteny: synteny at the sequence level, sub megase ...
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Summary: Structural variations (SVs) are large genomic rearrangements that vary significantly in size, making them challenging to detect with the relatively short reads from next-generation sequencing (NGS). Different SV detection methods have been developed; however, each is limited to specific kinds of SVs with varying accuracy and resolution. Previous works have attempted to combine differen...
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Comparative mapping of two species allows the observation of chromosomal segments conserved in both genomes since divergence from a common ancestor. Statistical analysis of the distribution of genes in these segments leads to an estimation of the number of unobserved segments, i.e., those containing no homologous genes identified as yet in the two genomes, possibly far more numerous than the ob...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2006
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0020075